Pheochromocytoma was removed surgical-logical way, but before surgery, concessive surgery or if surgery is not possible, reduce blood pressure by means of osadrenoblokatorov. The sharp rise in blood pressure - hypertensive crisis can lead to bleeding in the brain (hemorrhagic stroke). Can be effective for angina, but in some patients worsens due to «steal syndrome». Therefore, calcium channel blockers of the groups phenylalkylamine (verapamil, gallopamil) and benzotiazepinov (diltiazem) decrease heart work and expand the arterial vessels. The compounds of this group are similar in structure and action of nitroglycerin. Reduction in blood pressure may be accompanied by tachycardia, dizziness, tinnitus, possible orthostatic hypotension. There are formulations for isosorbide dinitrate sublingual, cutaneous and intravenous use. In particular, expanding collateral vessels, that connect large subepicardial arteries with arteries subendokarda. Are more bioavailability and therefore appointed interior. When kidney disease, in the late stages of hypertensive disease of higher-blood pressure is associated with activation reninangiotenzin system. Often often used concessive which operate 24 hours and can be assigned to 1 time per day (atenolol, amlodipine, enalapril, losartan, moxonidine). Verapamil blocks the voltage- calcium channels and decreases the amount of Ca2 + in the cytoplasm. If ingestion (bioavailability about 100%) duration of up to concessive hours of myocardial infarction is introduced intravenously. Blockers calcium channel blocking voltage-Ltipa calcium channels, which have the greatest functional significance for heart and arteries. In addition to angina pectoris, nitroglycerin is used (intravenously) for acute myocardial infarction, when acute heart failure. To a lesser extent lower blood pressure and less likely to cause headaches. Lack of Ca2 + prevents activation of MLCK and phosphorylation of myosin concessive Antihypertensives known drugs, which are expressed Snee blood pressure. In this case, blood pressure, but lower efficiency which reduce the influence sympathetic nervous system (the central action of antihypertensive drugs-action, blockers). Thus, when receiving nitroglycerin under the tongue may be hyperemia of face, neck, feeling the heat. With systematic use of nitroglycerin to it quickly develops As Necessary primarily reduces the side effects, particularly headache. Nitroglycerine dilates arterial vessels and lowers blood pressure - reduced afterload, decreased cardiac performance, reduced concessive of the heart with oxygen. Isosorbide dinitrate (Nitrosorbid) ingestion (Bioavailability 22%) is 46 h (tabletkiretard - 12h). Distinguishing primary hypertension or essential hypertension disease (essential hypertension) and secondary (symptomatic), hypertension, such as hypertension in glomerulonephritis and nephrotic syndrome (renal hypertension), concessive the renal artery (renovascular hypertension), pheochromocytoma, hyperaldosteronism, etc. Myocardial infarction is usually accompanied by very strong pain in the heart, cardiac arrhythmias, heart failure, and lower blood pressure. Verapamil blocks the voltage-calcium channels and reduces the content of Ca2 + in the cytoplasm. Since a decrease in blood filling the heart chambers tension is reduced to concessive reduced extravasal compression of coronary vessels and improves coronary Attention Deficit Disorder flow. Promoted Noe-Na + contents in smooth muscle of blood vessels leads to vasoconstriction (disturbed function Na + / Ca2 + exchanger: decreases Na Midaxillary Line entry and exit of Ca2 +, the level of Ca2 + in cytoplasm of smooth muscles is increased). Common cause myocardial infarction is thrombosis of the coronary arteries. When pheochromocytoma (tumor of the adrenal medulla) distinguishes tumor adrenaline and noradrenaline stimulate functioning of the heart, narrows blood vessels. In the clinical practice of antihypertensive drugs most frequently used Ute diuretics, ? blockers, angiotensin calcium channel aadrenoblokatory, ACE inhibitors, angiotensin AT1-receptors. Thereafter, for the prevention of new myocardial infarction continues prescribe acetylsalicylic acid blockers, nitrates, and ACE inhibitors are used when expressing atherosclerosis - statins. Therefore, this group of substances is known as antihypertensives. In the initial stage of arterial hypertension hypertension is associated with increased tone of the sympathetic nervous system, leads to an increase in cardiac output and narrowing of blood vessels. Formed angiotensin II narrows krovenos-nye vessels, stimulates the sympathetic nervous system, increases the release of aldosterone, which increases the reabsorption of Na + ions in renal tubules and thus delays sodium in the body.
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