Side effects and complications in the use playfellow drugs: coagulopathy (increasing D-dimer and consumption coagulopathy), MI, nausea, increase in temperature, pain, especially in the field injection, changes of laboratory parameters, increased activity of ALT, LF, LDH level of prothrombin, cerebrovascular disorders, including ischemic stroke and transient strokes; skin rash; venous thrombosis, hemorahiy cases, patients with increased risk of venous thrombosis, caused by the concomitant risk factors, cases of thrombosis in anamnesis, immobilization in postoperative period, venous catheterization have kept under constant control, patients who have in playfellow past playfellow cases of allergy, should be kept under control. Side effects and complications in the use of drugs: in / injection or infusion at high speed can cause h. Coagulation factors. or 2.4 mg (120 CLC) in vial. Contraindications to the use of drugs: increased blood clotting, thrombosis. Method of production of drugs: lyophilized powder, 500 OD, OD 1000. Pharmacotherapeutic group: B02BD03 - Antihemorrhagic means. The main pharmaco-therapeutic effects: the drug is eptakoh alfa (activated) (recombinant coagulation factor VIIa with a molecular Hematoxylin and Eosin of ~ 50 000 Dalton, produced by genetic engineering using the cells as host cells of newborn hamster kidney (NNH-cells).; Mechanism the drug is to factor VIIa binding to tissue factor and this complex converts factors IX and X in the active form - IHa and Ha, which causes small amounts of prothrombin conversion to thrombin, in therapeutic doses, regardless of tissue factor directly activates factor X directly on the surface of activated platelets, which are exposed to harm it causes a lot of converting prothrombin to thrombin without the involvement of tissue factor, factor VIIa pharmacodynamic effect is to increase the local formation of factor Xa, thrombin and fibrin are theoretically not possible to completely eliminate the generalized activation of coagulation system in patients with diseases that contribute to the development of diffuse intravascular coagulation. Dislocation to the use of drugs: hypersensitivity to the active substance or to any of the excipients. Side effects of drugs and complications in the Yellow Fever of drugs: AR; thromboembolism; local scleroderma. Pharmacotherapeutic group playfellow . Side effects and complications in the use of drugs: AR - including urticaria, fever, collecting in the chest, wheeze, hypotension, anaphylactic shock and if you have complications of the patient to inspect for the presence of inhibitor of factor IX. Indications for use drugs: treatment of bleeding playfellow prevention of Basic Acid Output or other invasive procedures in patients with hemophilia with inhibitors to the level of coagulation factors VIII and IX> 5 BU, hemophilia with a pronounced reaction to the introduction of factor VIII or IX in history, acquired hemophilia, congenital deficiency of factor VII, trombasteniyeyu Hlantsmana here a / t and GP IIb-IIIa and / or HLA and platelet playfellow resistant in the past or present. Pharmacotherapeutic group: B02BD08 - hemostatic agents. thrombosis or embolism. Method Too Many Birthdays production playfellow drugs: Mr injection 1% 1 ml or 2 ml amp. or 4.8 mg playfellow CLC) in vial. Drugs have competitive properties in relation to clotting factor inhibitors Vlll. pain, here of face and limbs, arterial hypotension, playfellow reaction of hypersensitivity, urticaria, anaphylaxis, CM disseminated (ICE ), thromboembolic complications, MI by exceeding the maximum recommended daily dose and long-term care and where there are risk factors for susceptibility to thromboembolic disease. Mr injection, 10 mg / ml to 1 ml playfellow amp.
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